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Synaptophysin Antibody (701503) in ICC/IF
Immunofluorescent analysis of Synaptophysin was done on Primary Rat Hippocampus neuronal cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with Synaptophysin Recombinant Rabbit Monoclonal Antibody (Product # 701503) at a dilution of 1:400 in 1% BSA and incu... View More
产品信息
701503
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8H2L12
抗原
Human Synaptophysin
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532488
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BM89 antigen; Major synaptic vesicle protein p38; Synaptophysin; Syp I
基因别名: A230093K24Rik; AI848995; MRX96; MRXSYP; p38; Syn; SYP; Syp1
UniProt ID: (Human) P08247, (Rat) P07825, (Mouse) Q62277
Entrez Gene ID: (Human) 6855, (Rat) 24804, (Mouse) 20977
endocytosis
synaptic vesicle maturation
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
synaptic vesicle membrane organization
cellular response to organic substance
regulation of opioid receptor signaling pathway
transport
chemical synaptic transmission
