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产品信息
PA5-20529
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid peptide from near the center of human Syntaphilin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155821
产品详细信息
Despite its predicted molecular weight, Syntaphilin often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is rat brain tissue lysate.
PA5-20529 can be used with blocking peptide PEP-0649.
靶标信息
Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bA314N13.5; Syntaphilin
基因别名: 6430515A01; AW045671; AW556958; AW743098; KIAA0374; mKIAA0374; SNPH
UniProt ID: (Human) O15079, (Rat) B5DF41, (Mouse) Q80U23
Entrez Gene ID: (Human) 9751, (Rat) 296267, (Mouse) 241727
