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Syntaxin 1 Antibody (PA5-28431) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of Syntaxin 1 was performed in DIV9 rat E18 primary cortical neurons fixed in 4% paraformaldehyde at RT for 15 min. Green: Syntaxin 1 Polyclonal Antibody (Product # PA5 28431) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, a neuron cell marker. Blue: Fluoroshield with DAPI.
产品信息
PA5-28431
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 1 and 43 of Human Syntaxin 1a
偶联物
形式
Liquid
浓度
9.3 mg/mL
纯化类型
Protein A
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545907
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2, Molt-4.
Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Neuron-specific antigen HPC-1; P35A; STX1B; STX1B1; STX1B2; STXA1; Synaptotagmin-associated 35 kDa protein; syntaxin 1A (brain); syntaxin 1A (brain)-like; Syntaxin-1A; Syntaxin-1B1; Syntaxin-1B2
基因别名: HPC-1; P35-1; Sap; STX1; STX1A; SYN1A
UniProt ID: (Human) Q16623, (Rat) P32851
Entrez Gene ID: (Human) 6804, (Rat) 116470
SNARE binding
glycoprotein binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein domain specific binding
protein binding, bridging
myosin head/neck binding
ATP-dependent protein binding
ion channel binding
protein heterodimerization activity
protein N-terminus binding
calcium-dependent protein binding
SNARE protein
positive regulation of neurotransmitter secretion
intracellular protein transport
neurotransmitter secretion
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
glutamate secretion
synaptic vesicle docking
synaptic vesicle fusion to presynaptic active zone membrane
secretion by cell
positive regulation of catecholamine secretion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
regulation of insulin secretion
positive regulation of excitatory postsynaptic potential
neurotransmitter transport
calcium ion regulated exocytosis
regulation of exocytosis
positive regulation of exocytosis
