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产品信息
MA5-33090
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM367
抗原
A peptide corresponding to residues near the N-terminus of human Syntaxin-1A.
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2810182
产品详细信息
Specificity: reacts to human, mouse, and rat Syntaxin-1A.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Neuron-specific antigen HPC-1; P35A; STX1B; STX1B1; STX1B2; STXA1; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; Syntaxin-1A; Syntaxin-1B1; Syntaxin-1B2
基因别名: HPC-1; P35-1; Sap; STX1; STX1A; SYN1A
UniProt ID: (Human) Q16623, (Mouse) O35526, (Rat) P32851
Entrez Gene ID: (Human) 6804, (Mouse) 20907, (Rat) 116470
SNARE binding
glycoprotein binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein domain specific binding
protein binding, bridging
myosin head/neck binding
ATP-dependent protein binding
ion channel binding
protein heterodimerization activity
protein N-terminus binding
calcium-dependent protein binding
SNARE protein
positive regulation of neurotransmitter secretion
intracellular protein transport
neurotransmitter secretion
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
glutamate secretion
synaptic vesicle docking
synaptic vesicle fusion to presynaptic active zone membrane
secretion by cell
positive regulation of catecholamine secretion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
regulation of insulin secretion
positive regulation of excitatory postsynaptic potential
transport
neurotransmitter transport
exocytosis
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
positive regulation of exocytosis
