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产品信息
PA5-28683
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 210 and 504 of Human TAB1
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546159
产品详细信息
Recommended positive controls: A431, Molt-4, Neuro 2A, C8D30, NIH-3T3, Raw264.7, PC-12, Rat2.
Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (81%), Pig (97%), Chicken (91%), Rhesus Monkey (100%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. It can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: beta activated kinase-1 binding protein-1; MGC57664; mitogen activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; RP3-407F17.2; TAB1beta; TAK1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
基因别名: 2310012M03Rik; 3'-Tab1; b2b449Clo; MAP3K7IP1; TAB1
UniProt ID: (Human) Q15750, (Mouse) Q8CF89
Entrez Gene ID: (Human) 10454, (Mouse) 66513, (Rat) 315139
activation of MAPKKK activity
activation of MAPK activity
in utero embryonic development
stimulatory C-type lectin receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
heart morphogenesis
cardiac septum development
protein dephosphorylation
transforming growth factor beta receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
lung development
aorta development
Fc-epsilon receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
coronary vasculature development
nucleotide-binding oligomerization domain containing signaling pathway
positive regulation of MAP kinase activity
metabolic process
