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产品信息
PA5-34247
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human TACR3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551599
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Gibbon, Monkey, Bat, Elephant, Rabbit, Pig (94%).
靶标信息
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
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生物信息学
蛋白别名: Neurokinin B; Neurokinin B receptor; neurokinin beta receptor; Neuromedin-K receptor; NK-3 receptor; NK-3R; NK3R TAC3R; NKR; Nmk-r; Tachykinin receptor 3
基因别名: HH11; NK-3R; NK3R; NKR; TAC3R; TAC3RL; TACR3
UniProt ID: (Human) P29371
Entrez Gene ID: (Human) 6870
tachykinin receptor signaling pathway
aging
positive regulation of heart rate
response to estradiol
regulation of dopamine metabolic process
response to cocaine
hyperosmotic salinity response
response to morphine
positive regulation of blood pressure
regulation of feeding behavior
positive regulation of uterine smooth muscle contraction
