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TAL1 Antibody (720233) in WB
Western blot analysis was performed on Nuclear enriched extracts (30 µg lysate) of HEL 92.1.7 (Lane 1), K-562 (Lane 2), MOLT4 (Lane 3), Jurkat (Lane 4), HUVEC (Lane 5) and HL-60 (Lane 6). The blots were probed with Anti-SCL (TAL-1) Rabbit Polyclonal Antibody (Product # 720233, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 17 kDa band corresponding to SCL (TAL-1) was observed across the cell lines tested *n... View More
Product Details
720233
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human TAL1 (aa 3-15)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2633208
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Pig, Bovine and Mouse
Target Information
TAL-1 is a basic helix-loop-helix transcription. It regulates differentiation and survival during hemopoiesis. TAL-1 is also implicated in the genesis of hemopoietic malignancies and it may play an important role in hemopoietic differentiation. It serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. TAL-1 is know to bind to the LIM domain containing protein Rhombotin-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa17; Class A basic helix-loop-helix protein 17; HGNC:11556; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product
Gene Aliases: BHLHA17; SCL; tal-1; TAL1; TCL5
UniProt ID: (Human) P17542
Entrez Gene ID: (Human) 6886
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
histone deacetylase binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
locomotory behavior
spinal cord association neuron differentiation
hemopoiesis
erythrocyte differentiation
megakaryocyte differentiation
platelet formation
basophil differentiation
positive regulation of protein complex assembly
embryonic hemopoiesis
megakaryocyte development
regulation of cell proliferation
erythrocyte maturation
cell fate commitment
positive regulation of erythrocyte differentiation
positive regulation of chromatin assembly or disassembly
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cell division
astrocyte fate commitment
definitive hemopoiesis
hemangioblast cell differentiation
hematopoietic stem cell differentiation
regulation of mast cell differentiation
regulation of stem cell population maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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