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TAL1 Antibody (PA5-30586) in IHC (P)
TAL1 Polyclonal Antibody detects TAL1 protein at cytosol and nucleus on mouse spleen by immunohistochemical analysis. Sample: Paraffin-embedded mouse spleen. TAL1 Polyclonal Antibody (Product # PA5-30586) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-30586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 252 and 331 of Human TAL1
Conjugate
Form
Liquid
Concentration
1.61 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2548060
Product Specific Information
Recommended positive controls: H1299.
Predicted reactivity: Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TAL-1 is a basic helix-loop-helix transcription. It regulates differentiation and survival during hemopoiesis. TAL-1 is also implicated in the genesis of hemopoietic malignancies and it may play an important role in hemopoietic differentiation. It serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. TAL-1 is know to bind to the LIM domain containing protein Rhombotin-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLHa17; Class A basic helix-loop-helix protein 17; HGNC:11556; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1 homolog; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product
Gene Aliases: BHLHA17; SCL; SCL/tal-1; Tal-1; TAL1; TCL5
UniProt ID: (Human) P17542, (Mouse) P22091
Entrez Gene ID: (Human) 6886, (Mouse) 21349
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
histone deacetylase binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding
transcription regulatory region sequence-specific DNA binding
DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
locomotory behavior
spinal cord association neuron differentiation
hemopoiesis
erythrocyte differentiation
megakaryocyte differentiation
platelet formation
basophil differentiation
positive regulation of protein complex assembly
embryonic hemopoiesis
megakaryocyte development
regulation of cell proliferation
erythrocyte maturation
cell fate commitment
positive regulation of erythrocyte differentiation
positive regulation of chromatin assembly or disassembly
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cell division
astrocyte fate commitment
definitive hemopoiesis
hemangioblast cell differentiation
hematopoietic stem cell differentiation
regulation of mast cell differentiation
regulation of stem cell population maintenance
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
myeloid cell differentiation
cell differentiation
neuron differentiation
regulation of myeloid cell differentiation
generation of neurons
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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