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产品信息
PA5-17349
产品规格
种属反应
Bovine,
Dog,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues surrounding Ser357 of human TANK
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10979031
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappa-B. This activation of NF-kappa-B occurs through an association with the kinases IKK-iota and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the Ikappa-B complex. This suggests that in addition to the possibility that TBK1 and IKK-iota activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: I-TRAF; OTTHUMP00000200694; OTTHUMP00000200695; OTTHUMP00000200696; OTTHUMP00000200698; OTTHUMP00000200700; OTTHUMP00000200703; OTTHUMP00000200704; TRAF family member-associated Nf-kappa B activator; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF interacting protein TANK; TRAF-interacting protein
基因别名: BOS_1791; C86182; E430026L09Rik; I-TRAF; ITRAF; TANK; TRAF2
UniProt ID: (Human) Q92844, (Mouse) P70347
Entrez Gene ID: (Bovine) 539513, (Dog) 608092, (Human) 10010, (Rat) 252961, (Mouse) 21353
I-kappaB kinase/NF-kappaB signaling
proteolysis
cellular response to DNA damage stimulus
signal transduction
TRIF-dependent toll-like receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to ionizing radiation
positive regulation of protein deubiquitination
positive regulation of ubiquitin-specific protease activity
