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TBLR1 Antibody (PA5-116008) in IHC (P)
Immunohistochemistry analysis of TBLR1 in human kidney cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-116008) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-116008
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TBL1XR1(Accession Q9BZK7), corresponding to amino acid residues K102-D152.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900642
产品详细信息
Antibody detects endogenous levels of total TBLR1.
靶标信息
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; nuclear receptor co-repressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1
基因别名: 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; IRA1; MRD41; RGD1560053; TBL1XR1; TBLR1
UniProt ID: (Human) Q9BZK7, (Mouse) Q8BHJ5
Entrez Gene ID: (Human) 79718, (Rat) 365755, (Mouse) 81004
negative regulation of transcription from RNA polymerase II promoter
response to dietary excess
transcription, DNA-templated
lipid catabolic process
histone deacetylation
regulation of cAMP metabolic process
multicellular organism growth
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular lipid metabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
white fat cell differentiation
canonical Wnt signaling pathway
fat pad development
regulation of triglyceride metabolic process
regulation of transcription from RNA polymerase II promoter
biological_process
regulation of gene expression
negative regulation of transcription, DNA-templated
adipose tissue development
regulation of transcription, DNA-templated
chromatin modification
