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TBX1 Antibody (34-9800) in IHC (P)
Immunohistochemistry analysis of T-BOX 1 showing staining in the cytoplasm and weak staining in the nucleus of paraffin-embedded mouse skeletal muscle tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2... View More
产品信息
34-9800
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from the internal region of the mouse T-box 1 (Tbx1) protein.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2533191
靶标信息
TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: T-box protein 1; T-box transcription factor TBX1; Testis-specific T-box protein
基因别名: Tbx1
UniProt ID: (Mouse) P70323
Entrez Gene ID: (Mouse) 21380
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
blood vessel development
patterning of blood vessels
cell fate specification
neural crest cell migration
positive regulation of protein phosphorylation
lymph vessel development
blood vessel remodeling
positive regulation of mesenchymal cell proliferation
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
determination of left/right symmetry
pattern specification process
mesoderm development
heart development
muscle organ development
sensory perception of sound
cell proliferation
positive regulation of cell proliferation
anterior/posterior pattern specification
vagus nerve morphogenesis
epithelial cell differentiation
thyroid gland development
social behavior
aorta morphogenesis
ear morphogenesis
inner ear morphogenesis
outer ear morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
muscle cell fate commitment
positive regulation of MAPK cascade
tongue morphogenesis
cellular response to fibroblast growth factor stimulus
negative regulation of cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
blood vessel morphogenesis
thymus development
muscle organ morphogenesis
embryonic cranial skeleton morphogenesis
embryonic viscerocranium morphogenesis
semicircular canal morphogenesis
artery morphogenesis
positive regulation of epithelial cell proliferation
parathyroid gland development
soft palate development
pharyngeal system development
face morphogenesis
muscle tissue morphogenesis
coronary artery morphogenesis
enamel mineralization
otic vesicle morphogenesis
positive regulation of secondary heart field cardioblast proliferation
cochlea morphogenesis
mesenchymal cell apoptotic process
regulation of organ morphogenesis
positive regulation of tongue muscle cell differentiation
negative regulation of mesenchymal cell apoptotic process
