Invitrogen

TBX1 Monoclonal Antibody (OTI1C2)

1 篇参考文献

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抗体检测数据 (2)

TBX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TBX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TBX1 Antibody (MA5-26348) in IHC (P)

Immunohistochemistry was performed on paraffin-embedded human lymph node tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a TBX1 monoclonal antibody (Product # MA5-26348).

TBX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TBX1 Antibody in Western Blot (WB)

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TBX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry was performed on paraffin-embedded human lymph node tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a TBX1 monoclonal antibody (Product # MA5-26348).

TBX1 Antibody in Western Blot (WB) — Western blot analysis of TBX1 in HEK293T cells in untransfected (Left lane) and transfected (Right lane) samples using 5 µg per lane. The samples were separated by SDS-PAGE and probed with TBX1 (Product # MA5-26348) monoclonal antibody.

产品信息

MA5-26348

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:4,000

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免疫组化（石蜡） (IHC (P))

1:150

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产品规格

种属反应

Human

已发表种属

Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OTI1C2

抗原

Full length human recombinant protein of TBX1 produced in HEK293T cell

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2725483

靶标信息

TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by Targeting TBX1 through the JAK2/STAT1 Pathway.

Cytogenetic and genome research

Cao ML,Zhu BL,Sun YY,Qiu GR,Fu WN,Jiang HK

MA5-26348 was used in Western Blot to investigate the role of miR-144 and TBX1 in cardiac development by studying the regulatory relationship and mechanism of miR-144 on TBX1/JAK2/STAT1 in cardiomyocytes.

Wed Mar 11 00:00:00 UTC 2020

生物信息学

蛋白别名: brachyury; T-box 1 transcription factor C; T-box protein 1; T-box transcription factor TBX1; Testis-specific T-box protein

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基因别名: CAFS; CATCH22; CTHM; DGCR; DGS; DORV; TBX1; TBX1C; TGA; VCF; VCFS

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UniProt ID: (Human) O43435

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Entrez Gene ID: (Human) 6899

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transcription factor activity, sequence-specific DNA binding protein homodimerization activity sequence-specific DNA binding Rel homology transcription factor

angiogenesis blood vessel development cell fate specification neural crest cell migration positive regulation of protein phosphorylation lymph vessel development positive regulation of mesenchymal cell proliferation heart morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis transcription, DNA-templated regulation of transcription from RNA polymerase II promoter determination of left/right symmetry pattern specification process mesoderm development heart development muscle organ development sensory perception of sound cell proliferation positive regulation of cell proliferation anterior/posterior pattern specification vagus nerve morphogenesis epithelial cell differentiation thyroid gland development social behavior aorta morphogenesis ear morphogenesis inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth muscle cell fate commitment positive regulation of MAPK cascade tongue morphogenesis cellular response to fibroblast growth factor stimulus negative regulation of cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway blood vessel morphogenesis thymus development muscle organ morphogenesis embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis semicircular canal morphogenesis artery morphogenesis positive regulation of epithelial cell proliferation parathyroid gland development soft palate development pharyngeal system development face morphogenesis muscle tissue morphogenesis coronary artery morphogenesis enamel mineralization cellular response to retinoic acid cochlea morphogenesis mesenchymal cell apoptotic process regulation of organ morphogenesis positive regulation of tongue muscle cell differentiation negative regulation of mesenchymal cell apoptotic process