Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
TBX2/3 Polyclonal Antibody
FIGURE: 1 / 2
TBX2/3 Antibody (PA5-116010) in ICC/IF
Immunocytochemistry analysis of TBX2/3 in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-116010). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-116010
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TBX3(Accession O15119), corresponding to amino acid residues A283-N333.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900644
Product Specific Information
Antibody detects endogenous levels of total TBX 2/3.
Target Information
TBX2 (T-Box Transcription Factor 2) is a Protein Coding gene. Diseases associated with TBX2 include Vertebral Anomalies And Variable Endocrine And T-Cell Dysfunction and Ulnar-Mammary Syndrome. Among its related pathways are Heart Development and Inhibition of Ribosome Biogenesis by p14(ARF). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is TBX3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: bladder cancer related protein XHL; T-box 3 (ulnar mammary syndrome); T-box protein 2; T-box protein 3; T-box transcription factor TBX2; T-box transcription factor TBX3; TBX2; TBX3; TBX3/2
Gene Aliases: D5Ertd189e; TBX2; TBX3; TBX3-ISO; UMS; XHL
UniProt ID: (Human) Q13207, (Human) O15119, (Mouse) Q60707, (Mouse) P70324, (Rat) Q7TST9
Entrez Gene ID: (Human) 6909, (Human) 6926, (Mouse) 21385, (Rat) 303398, (Mouse) 21386, (Rat) 353305
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein binding
sequence-specific DNA binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
transcription factor activity, sequence-specific DNA binding
molecular_function
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
heart looping
outflow tract septum morphogenesis
outflow tract morphogenesis
endocardial cushion morphogenesis
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription, DNA-templated
Notch signaling pathway
muscle cell fate determination
cell aging
regulation of heart contraction
positive regulation of cell proliferation
embryonic heart tube development
aorta morphogenesis
atrioventricular canal development
embryonic digit morphogenesis
negative regulation of transcription, DNA-templated
embryonic camera-type eye morphogenesis
cardiac muscle tissue development
palate development
positive regulation of cardiac muscle cell proliferation
pharynx development
developmental growth involved in morphogenesis
mammary placode formation
cellular senescence
negative regulation of heart looping
negative regulation of cardiac chamber formation
skeletal system development
blood vessel development
in utero embryonic development
atrioventricular bundle cell differentiation
regulation of transcription from RNA polymerase II promoter
anterior/posterior axis specification, embryo
organ morphogenesis
specification of organ position
stem cell population maintenance
limbic system development
male genitalia development
female genitalia development
negative regulation of epithelial cell differentiation
mammary gland development
luteinizing hormone secretion
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
forelimb morphogenesis
negative regulation of apoptotic process
negative regulation of myoblast differentiation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
follicle-stimulating hormone secretion
mesoderm morphogenesis
ventricular septum morphogenesis
branching involved in mammary gland duct morphogenesis
cardiac muscle cell fate commitment
sinoatrial node cell development
positive regulation of stem cell proliferation
heart morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
limb morphogenesis
regulation of cell proliferation
cardiac muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support