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TCAP Antibody (PA5-89304) in WB
Western blot analysis of TCAP in 293-TCAP cells. Samples were incubated with TCAP Polyclonal antibody (Product # PA5-89304) using a dilution of 1:400, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
PA5-89304
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_0036641)
偶联物
形式
Liquid
浓度
1.39 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805480
产品详细信息
Immunogen sequence: MATSELSCEV SEENCERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHQQGQCQVL VQRSPWLMMR MGILGRGLQE YQLPYQRVLP LPIFTPAKMG ATKEEREDTP IQLQELLALE TALGGQCVDR QEVAEITKQL PPVVPVSKPG ALRRSLSRSM SQEAQRG; Positive Samples: Mouse heart, Mouse skeletal muscle; Cellular Location: Cytoplasm, myofibril, sarcomere
靶标信息
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. TCAP is a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in TCAP gene are associated with limb-girdle muscular dystrophy type 2G.Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 19 kDa sarcomeric protein; limb girdle muscular dystrophy 2G (autosomal recessive); Telethonin; teneurin C-terminal associated peptide; Titin cap protein
基因别名: AI503981; AJ223855; CMD1N; CMH25; LGMD2G; T-cap; TCAP; TELE; telethonin
UniProt ID: (Human) O15273, (Mouse) O70548
Entrez Gene ID: (Human) 8557, (Rat) 688173, (Mouse) 21393
skeletal muscle contraction
cardiac muscle hypertrophy
adult heart development
cardiac muscle hypertrophy in response to stress
skeletal muscle thin filament assembly
skeletal muscle myosin thick filament assembly
detection of muscle stretch
sarcomere organization
cardiac muscle fiber development
sarcomerogenesis
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
cardiac muscle contraction
somitogenesis
protein complex assembly
muscle filament sliding
otic vesicle formation
response to muscle stretch
detection of mechanical stimulus
