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产品信息
PA5-20900
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the amino terminus of human TCF3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152186
产品详细信息
A suggested positive control is human brain tissue lysate.
PA5-20900 can be used with blocking peptide PEP-1014.
靶标信息
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bHLHb21; Class B basic helix-loop-helix protein 21; helix-loop-helix protein HE47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; MGC129647; MGC129648; negative vitamin D response element-binding protein; NOL1-TCF3 fusion; Pancreas specific transcription factor 1c; TCF-3; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); transcription factor 3 variant 3; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; Transcription factor ITF-1; Transcription regulator Pan; VDR interacting repressor; vitamin D receptor-interacting repressor
基因别名: A1; AA408400; AGM8; ALF2; AW209082; BHLHB21; E12; E12/E47; E2A; E47; ITF1; ME2; Pan; Pan1; Pan2; Ptf1c; TCF-3; TCF3; Tcfe2a; VDIR
UniProt ID: (Human) P15923, (Mouse) P15806, (Rat) P21677
Entrez Gene ID: (Human) 6929, (Mouse) 21423, (Rat) 171046
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
mitogen-activated protein kinase kinase kinase binding
enhancer binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
repressing transcription factor binding
vitamin D response element binding
E-box binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
chromatin binding
PDZ domain binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity
negative regulation of transcription from RNA polymerase II promoter
natural killer cell differentiation
B cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
gastrulation
nervous system development
positive regulation of gene expression
lymphocyte differentiation
cell differentiation
positive regulation of B cell proliferation
response to lipopolysaccharide
T cell differentiation in thymus
immunoglobulin V(D)J recombination
response to drug
histone H3 acetylation
histone H4 acetylation
positive regulation of neuron differentiation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
Peyer's patch development
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of G1/S transition of mitotic cell cycle
B cell differentiation
positive regulation of muscle cell differentiation
