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TCF3 Antibody (MA5-47234) in ICC/IF
Immunofluorescent analysis of TCF3 in HeLa cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: TCF3 / E2A stained by TCF3 / E2A monoclonal antibody (Product # MA5-47234) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] diluted at 1:1,000.
产品信息
MA5-47234
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1955
抗原
Recombinant fragment of human TCF3 / E2A
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938306
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb21; Class B basic helix-loop-helix protein 21; helix-loop-helix protein HE47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; MGC129647; MGC129648; negative vitamin D response element-binding protein; NOL1-TCF3 fusion; TCF-3; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); transcription factor 3 variant 3; Transcription factor E2-alpha; Transcription factor ITF-1; VDR interacting repressor; vitamin D receptor-interacting repressor
基因别名: AGM8; BHLHB21; E2A; E47; ITF1; TCF-3; TCF3; VDIR
UniProt ID: (Human) P15923
Entrez Gene ID: (Human) 6929
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
mitogen-activated protein kinase kinase kinase binding
enhancer binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
repressing transcription factor binding
vitamin D response element binding
E-box binding
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
B cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
B cell differentiation
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of muscle cell differentiation
