Invitrogen

TCF4/TCF12 Polyclonal Antibody

TCF4/TCF12 Antibody in Western Blot (WB)

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TCF4/TCF12 Antibody (PA5-106756) in WB

Western blot analysis of TCF4/TCF12 in mouse muscle lysate. Samples were incubated with TCF4/TCF12 polyclonal antibody (Product # PA5-106756).

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产品信息

PA5-106756

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human TCF4(Accession P15884), corresponding to amino acid residues K596-P646.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2854424

产品详细信息

Antibody detects endogenous levels of total TCF4/12.

靶标信息

T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group(HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to beta-catenin in a cooperative manner. This TCF-4/ beta-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: bHLHb19; bHLHb20; Class A helix-loop-helix transcription factor ME1; Class A helix-loop-helix transcription factor ME2; Class B basic helix-loop-helix protein 19; Class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein; helix-loop-helix transcription factor 4; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF-2; MITF-2; R8f DNA-binding protein; RITF-2; Salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBP-alpha; SEF-2; SL3-3 enhancer factor 2; TCF-12; TCF-4; Transcription factor 12; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R; Transcription factor HTF-4

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基因别名: 5730422P05Rik; A130037E08Rik; ALF1; ASP-I2; BHLHB19; BHLHB20; CRS3; E2-2; E2.2; FECD3; HEB; HEBAlt; HsT17266; HTF-4; HTF4; ITF-2; ITF-2b; ITF2; ME1; ME2; Meb; MITF-2A; MITF-2B; PTHS; REB; SCBPA; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-12; TCF-4; TCF12; TCF4; TFE