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TCF7L1 Antibody (PA5-106757) in ICC/IF
Immunocytochemistry analysis of TCF7L1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with TCF7L1 polyclonal antibody (Product # PA5-106757) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-106757
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TCF7L1(Accession Q9HCS4), corresponding to amino acid residues P321-K371.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854425
产品详细信息
Antibody detects endogenous levels of total TCF7L1.
靶标信息
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HMG box transcription factor 3; T-cell factor 3; TCF-3; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); transcription factor 7-like 2 (T-cell specific, HMG box)
基因别名: bHLHb21; TCF-3; TCF3; TCF7L1
UniProt ID: (Human) Q9HCS4, (Mouse) Q9Z1J1
Entrez Gene ID: (Human) 83439, (Rat) 312451, (Mouse) 21415
chromatin organization
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of Wnt signaling pathway
canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
biological_process
anterior/posterior axis specification, embryo
somatic stem cell population maintenance
skin development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter during mitosis
axial mesoderm morphogenesis
stem cell differentiation
regulation of stem cell population maintenance
Wnt signaling pathway
generation of neurons
