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产品信息
PA5-93047
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 206-535 of human TCP1 beta/TCP1 beta/CCT2 (NP_0064221)
偶联物
形式
Liquid
浓度
1.26 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806601
产品详细信息
Immunogen sequence: GGSLADSYLD EGFLLDKKIG VNQPKRIENA KILIANTGMD TDKIKIFGSR VRVDSTAKVA EIEHAEKEKM KEKVERILKH GINCFINRQL IYNYPEQLFG AAGVMAIEHA DFAGVERLAL VTGGEIASTF DHPELVKLGS CKLIEEVMIG EDKLIHFSGV ALGEACTIVL RGATQQILDE AERSLHDALC VLAQTVKDSR TVYGGGCSEM LMAHAVTQLA NRTPGKEAVA MESYAKALRM LPTIIADNAG YDSADLVAQL RAAHSEGNTT AGLDMREGTI GDMAILGITE SFQVKRQVLL SAAEAAEVIL RVDNIIKAAP RKRVPDHHPC; Positive Samples: MCF7, SKOV3, A-549, HT-29, Mouse spleen, Mouse ovary, Mouse heart; Cellular Location: Cytoplasm
靶标信息
TCP-1 beta is a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). The CCT complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the TCP-1 beta gene have been observed but not thoroughly characterized. A disease associated with TCP-1 beta protein dysfunction include epididymo-orchitis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AI528772; c-cpn; CCT; CCT-beta; Cct1; Ccta; Chaperonin containing T-complex polypeptide 1 subunit 2; chaperonin containing t-complex polypeptide 1, beta subunit; chaperonin containing t-complex polypeptide 1, subunit 2; chaperonin containing TCP1, subunit 2 (beta); chaperonin subunit 2 (beta); epididymis secretory sperm binding protein Li 100n; p63; T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; Tcp-1; TCP-1-beta; Tp63; TRic
基因别名: 99D8.1; CCT-beta; CCT2; CCTB; HEL-S-100n; PRO1633; TCP-1-beta
UniProt ID: (Human) P78371, (Mouse) P80314
Entrez Gene ID: (Human) 10576, (Mouse) 12461
protein folding
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomerase
protein stabilization
chaperone mediated protein folding independent of cofactor
chaperone-mediated protein complex assembly
positive regulation of telomerase activity
scaRNA localization to Cajal body
toxin transport
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
