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TCP1 Antibody (MA5-34861) in IHC (P)
Immunohistochemistry analysis of TCP1 alpha/CCTA in paraffin-embedded human liver cancer tissue. Samples were heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4, 20 minutes) and blocked in 5% BSA (30 min, room temperature), incubated with TCP1 alpha/CCTA monoclonal antibody (Product # MA5-34861) at a dilution of 1:50 (30 min, room temperature), and followed by HRP conjugate, DAB and hematoxyl... View More
产品信息
MA5-34861
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE48-48
抗原
Recombinant protein within Human TCP1 alpha aa 1-97
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
RRID
AB_2848769
产品详细信息
Positive Control: Daudi, human liver cancer tissue, human skin tissue, human breast tissue.
靶标信息
The T Complex Polypeptide 1 (TCP-1) is approximately 60 kDa protein constitutively expressed in almost all eukaryotic cells, and is upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. The family of proteins termed chaperonins act to recognize and stabilize polypeptide intermediates during folding, assembly and disassembly, and share many characteristics with Heat Shock Protein 70 (HSP70) including high abundance, induction by environmental stress, and ATPase activity. The chaperonin family includes the mitochondrial HSP60, Escherichia coli GroEL, the plastid Rubisco-subunit binding protein, and the archaebacterial protein TF55. The TCP-1 sequence shows nearly 40% identity to TF55, but only minimal similarity to HSP60 and GroEL.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CCT-alpha; Chaperonin containing T-complex polypeptide 1 subunit 1; T-complex protein 1 subunit alpha; T-complex protein 1, alpha subunit; tailless complex polypeptide 1; TCP-1-alpha
基因别名: CCT-alpha; CCT1; CCTA; D6S230E; TCP-1-alpha; TCP1
UniProt ID: (Human) P17987
Entrez Gene ID: (Human) 6950
protein folding
tubulin complex assembly
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomerase
translocation of peptides or proteins into host cell cytoplasm
protein stabilization
positive regulation of telomerase activity
scaRNA localization to Cajal body
toxin transport
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
regulation of macrophage apoptotic process
