Invitrogen

TCR beta Monoclonal Antibody (H57-597), PE

TCR beta Antibody in Flow Cytometry (Flow)

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TCR beta Antibody (A15408) in Flow

Flow cytometry analysis of TCR beta in BALB/c mouse splenocytes. Cells were stained using TCR beta Monoclonal Antibody (H57-597), PE (Product # A15408) and Rat Anti-Mouse CD19-FITC.

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产品信息

A15408

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells

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其他PubMed (Misc)

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产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Armenian hamster / IgG2

分类

Monoclonal

类型

Antibody

克隆号

H57-597

抗原

TCR affinity purified from mouse T cell hybridoma DO-11.101

偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

purified

保存液

PBS, pH 7.5

内含物

<0.1% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2534421

靶标信息

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice.

Oncotarget

Wei Y,Lu C,Chen J,Cui G,Wang L,Yu T,Yang Y,Wu W,Ding Y,Li L,Uede T,Chen Z,Diao H

A15408 was used in flow cytometry to determine the effect of a high salt diet on intestinal immunity and the risk of inflammatory bowel disease

Tue Jan 03 00:00:00 UTC 2017

Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells.

Brain, behavior, and immunity

Mandal M,Marzouk AC,Donnelly R,Ponzio NM

A15408 was used in flow cytometry to examine how maternal immune stimulation affects the adaptive immune system and pathobiology of the offspring

Fri Jul 01 00:00:00 UTC 2011

Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity.

Journal of immunology (Baltimore, Md. : 1950)

Cawthon AG,Alexander-Miller MA

A15408 was used in flow cytometry to investigate the control of functional avidity in response to viral infection.

Tue Oct 01 00:00:00 UTC 2002

Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hayashi K,Natsume W,Watanabe T,Abe N,Iwai N,Okada H,Ito Y,Asano M,Iwakura Y,Habu S,Takahama Y,Satake M

A15408 was used in flow cytometry to investigate the role of AML1 in T cell development.

Fri Dec 15 00:00:00 UTC 2000

Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay.

The Journal of experimental medicine

Ikawa T,Kawamoto H,Fujimoto S,Katsura Y

A15408 was used in flow cytometry to describe a clonal system that supports the development of T and natural killer cells evenly.

Mon Dec 06 00:00:00 UTC 1999

Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.

Proceedings of the National Academy of Sciences of the United States of America

Dejbakhsh-Jones S,Strober S

A15408 was used in flow cytometry to identify a rare population of cells in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRalphabeta(+) T cells.

Tue Dec 07 00:00:00 UTC 1999

Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver.

Journal of immunology (Baltimore, Md. : 1950)

Kawamoto H,Ohmura K,Fujimoto S,Katsura Y

A15408 was used in flow cytometry to assess if progenitors colonizing the thymus are T cell lineage restricted.

Mon Mar 01 00:00:00 UTC 1999

Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse.

Journal of immunology (Baltimore, Md. : 1950)

Ohmura K,Kawamoto H,Fujimoto S,Ozaki S,Nakao K,Katsura Y

A15408 was used in flow cytometry to investigate the aorta-gonad-mesonephros region as a source of hemopoietic progenitors.

Mon Nov 01 00:00:00 UTC 1999

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

The Journal of experimental medicine

Pear WS,Aster JC,Scott ML,Hasserjian RP,Soffer B,Sklar J,Baltimore D

A15408 was used in flow cytometry to report that TAN1 is an oncoprotein.

Wed May 01 00:00:00 UTC 1996

Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules.

European journal of immunology

Ohteki T,Iwamoto M,Izui S,MacDonald HR

A15408 was used in flow cytometry to examine the origin of double negative T cells using Ipr mice.

Sun Jan 01 00:00:00 UTC 1995

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.

The Journal of experimental medicine

Ohteki T,MacDonald HR

A15408 was used in flow cytometry to investigate T cell subsets in the liver.

Mon Aug 01 00:00:00 UTC 1994

生物信息学

蛋白别名: bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; TCRbeta; TCRD; TRA

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基因别名: TCRbeta; Tib

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Entrez Gene ID: (Mouse) 21577

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TCR beta Monoclonal Antibody (H57-597), PE

TCR beta Antibody (A15408) in Flow

产品信息

A15408

流式细胞分析 (Flow)

其他PubMed (Misc)

种属反应

已发表种属

宿主/亚型

分类

类型

克隆号

抗原

偶联物

激发/发射光谱

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

靶标信息

How to use the Panel Builder

生物信息学

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