Bethyl Laboratories

TDG Polyclonal Antibody

TDG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TDG Antibody (A304-365A) in IHC (P)

Detection of human TDG by immunohistochemistry. Sample: FFPE section of human mammary glands. Antibody: Affinity purified rabbit anti-TDG (Product # A304-365A) (Lot 1) used at a dilution of 1:1,000 (1 µg/mL). Detection: DAB.

TDG Antibody in Immunoprecipitation (IP)

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产品信息

A304-365A

应用

建议稀释比

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免疫印迹 (WB)

1:2,000-1:10,000

免疫组化 (IHC)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:500-1:2,000

免疫沉淀 (IP)

2-10 µg/mg lysate

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Region between residue 360 to 410 of Human Thymine-DNA Glycosylase.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

tris citrate/phosphate, pH 7-8

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Wet ice

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

靶标信息

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.

仅用于科研。不用于诊断过程。未经明确授权不得转售。