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产品信息
MA5-31521
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
GT311
抗原
Recombinant protein encompassing a sequence within the center region of human TDG.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787152
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (99%), Xenopus laevis (92%), Chicken (95%), Bovine (99%).
Positive Control: human TDG -transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-JUN leucine zipper interactive protein JZA-3; G/T mismatch-specific thymine DNA glycosylase; hTDG; Thymine-DNA glycosylase
基因别名: E130317C12Rik; hTDG; JZA-3; Jza1; TDG
UniProt ID: (Human) Q13569, (Mouse) P56581
Entrez Gene ID: (Human) 6996, (Mouse) 21665
RNA polymerase II transcription cofactor activity
damaged DNA binding
double-stranded DNA binding
uracil DNA N-glycosylase activity
protein kinase C binding
protein binding
pyrimidine-specific mismatch base pair DNA N-glycosylase activity
DNA N-glycosylase activity
mismatched DNA binding
SUMO binding
protein homodimerization activity
structure-specific DNA binding
transcription factor binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
protein domain specific binding
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
base-excision repair
base-excision repair, AP site formation
mismatch repair
transcription, DNA-templated
embryo development
covalent chromatin modification
protein sumoylation
negative regulation of protein binding
oxidative DNA demethylation
negative regulation of chromatin binding
regulation of gene expression, epigenetic
depyrimidination
DNA demethylation
DNA repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
metabolic process
chromatin modification
