Abnova

TEK Polyclonal Antibody, MaxPab™

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TEK Antibody (H00007010-B01P) in WB

Western Blot analysis of TEK expression in transfected 293T cell line by TEK MaxPab polyclonal antibody. Lane 1: TEK transfected lysate(121.11 KDa). Lane 2: Non-transfected lysate. .

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产品信息

H00007010-B01P

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG

分类

Polyclonal

类型

Antibody

抗原

TEK (ABW03349.1, 1 a.a. approximately 1101 a.a) full-length human protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MDLILINSLP LVSDAETSLT CIASGWRPHE PITIGRDFEA LMNQHQDPLE VTQDVTREWA KKVVWKREKA SKINGAYFCE GRVRGEAIRI RTMKMRQQAS FLPATLTMTV DKGDNVNISF KKVLIKEEDA VIYKNGSFIH SVPRHEVPDI LEVHLPHAQP QDAGVYSARY IGGNLFTSAF TRLIVRRCEA QKWGPECNHL CTACMNNGVC HEDTGECICP PGFMGRTCEK ACELHTFGRT CKERCSGQEG CKSYVFCLPD PYGCSCATGW KGLQCNEACH PGFYGPDCKL RCSCNNGEMC DRFQGCLCSP GWQGLQCERE GIPRMTPKIV DLPDHIEVNS GKFNPICKAS GWPLPTNEEM TLVKPDGTVL HPKDFNHTDH FSVAIFTIHR ILPPDSGVWV CSVNTVAGMV EKPFNISVKV LPKPLNAPNV IDTGHNFAVI NISSEPYFGD GPIKSKKLLY KPVNHYEAWQ HIQVTNEIVT LNYLEPRTEY ELCVQLVRRG EGGEGHPGPV RRFTTASIGL PPPRGLNLLP KSQTTLNLTW QPIFPSSEDD FYVEVERRSV QKSDQQNIKV PGNLTSVLLN NLHPREQYVV RARVNTKAQG EWSEDLTAWT LSDILPPQPE NIKISNITHS SAVISWTILD GYSISSITIR YKVQGKNEDQ HVDVKIKNAT ITQYQLKGLE PETAYQVDIF AENNIGSSNP AFSHELVTLP ESQAPADLGG GKMLLIAILG SAGMTCLTVL LAFLIILQLK RANVQRRMAQ AFQNVREEPA VQFNSGTLAL NRKVKNNPDP TIYPVLDWND IKFQDVIGEG NFGQVLKARI KKDGLRMDAA IKRMKEYASK DDHRDFAGEL EVLCKLGHHP NIINLLGACE HRGYLYLAIE YAPHGNLLDF LRKSRVLETD PAFAIANSTA STLSSHHLLH FAADVARGMD YLSQKQFIHR DLAARNILVG ENYVAKIADF GLSRGQEVYV KKTMGRLPVR WMAIESLNYS VYTTNSDVWS YGVLLWEIVS LGGTPYCGMT CAELYEKLPQ GYRLEKPLNC DDEVYDLMRQ CWREKPYERP SFAQILVSLN RMLEERKTYV NTTLYEKFTY AGIDCSAEEA A

靶标信息

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; hTIE2; p140 TEK; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2

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基因别名: CD202B; TEK; TIE-2; TIE2; VMCM; VMCM1

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UniProt ID: (Human) Q02763

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Entrez Gene ID: (Human) 7010

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功能

protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding growth factor binding transmembrane signal receptor

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