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产品信息
MA5-46686
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
116
抗原
Recombinant protein ecoding Human TEK (Met1-Lys745).
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein A
保存液
PBS with 0.5% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2937758
产品详细信息
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human TIE2 (TEK) (Met1-Lys745) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
靶标信息
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; hTIE2; p140 TEK; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2
基因别名: CD202B; TEK; TIE-2; TIE2; VMCM; VMCM1
UniProt ID: (Human) Q02763
Entrez Gene ID: (Human) 7010
MAPK cascade
angiogenesis
response to hypoxia
positive regulation of protein phosphorylation
endothelial cell proliferation
positive regulation of endothelial cell proliferation
endochondral ossification
sprouting angiogenesis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell-cell signaling
heart development
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
peptidyl-tyrosine phosphorylation
organ regeneration
regulation of establishment or maintenance of cell polarity
substrate adhesion-dependent cell spreading
negative regulation of apoptotic process
regulation of vascular permeability
response to peptide hormone
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of angiogenesis
protein autophosphorylation
Tie signaling pathway
negative regulation of inflammatory response
leukocyte migration
protein oligomerization
response to cAMP
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
definitive hemopoiesis
heart trabecula formation
positive regulation of ERK1 and ERK2 cascade
positive regulation of intracellular signal transduction
positive regulation of actin cytoskeleton reorganization
regulation of endothelial cell apoptotic process
negative regulation of endothelial cell apoptotic process
