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产品信息
PA5-33618
产品规格
种属反应
Bat,
Dog,
Horse,
Human,
Non-human primate,
Pig,
Rabbit
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GPR124.
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550996
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig, Opossum (100%).
靶标信息
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
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生物信息学
蛋白别名: Adhesion G protein-coupled receptor A2; DKFZp434C211; DKFZp434J0911; FLJ14390; G protein-coupled receptor 124; G-protein coupled receptor 124; Tumor endothelial marker 5
基因别名: ADGRA2; GPR124; KIAA1531; TEM5
UniProt ID: (Human) Q96PE1
Entrez Gene ID: (Rabbit) 100339596, (Dog) 482853, (Human) 25960, (Pig) 100524344, (Horse) 100059646
sprouting angiogenesis
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
central nervous system development
positive regulation of endothelial cell migration
endothelial cell migration
regulation of angiogenesis
regulation of chemotaxis
regulation of establishment of blood-brain barrier
negative regulation of vascular endothelial growth factor signaling pathway
