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产品信息
PA5-20016
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide corresponding to 13 amino acids near the center of human TEM8.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ion-exchange chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11156593
产品详细信息
This antibody recognizes all three isoforms.
A suggested positive control is HepG2 cell lysate.
PA5-20016 can be used with blocking peptide PEP-0135.
靶标信息
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; Anthrax toxin receptor 1; FLJ10601; FLJ11298; FLJ21776; Tem-8; Tumor endothelial marker 8
基因别名: 2310008J16Rik; 2810405N18Rik; Antrx1; ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2, (Rat) Q0PMD2, (Mouse) Q9CZ52
Entrez Gene ID: (Human) 84168, (Rat) 362393, (Mouse) 69538
