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TEP1 Antibody (PA5-97264) in WB
Western blot analysis of TEP1 in extracts of DU145 cells. Samples were incubated with TEP1 Polyclonal antibody (Product # PA5-97264) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-97264
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 2523-2627 of human TEP1 (NP_0090412)
偶联物
形式
Liquid
浓度
0.82 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2809066
产品详细信息
Immunogen sequence: TCRESDASMD SDASMDSEPT PHLKTRQRRK IHSGSVTALH VLPELLVTAS KDRDVKLWER PSMQLLGLFR CEGSVSCLEP WLGANSTLQL AVGDVQGNVY FLNWE; Positive Samples: DU145; Cellular Location: Chromosome, Nucleus, telomere
靶标信息
Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p240; p80 telomerase homolog; Telomerase protein 1; Telomerase protein component 1; Telomerase-associated protein 1; TROVE domain family, member 1
基因别名: p240; TEP1; TLP1; TP1; TROVE1; VAULT2
UniProt ID: (Human) Q99973
Entrez Gene ID: (Human) 7011
