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Positive Control: Human tonsil tissue, human liver tissue, human colon cancer tissue, human kidney tissue, A431, A549, PC-3M.
TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-alpha induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-alpha are cross-species reactive. TGFalpha (aa 50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Protransforming growth factor alpha; TGF a; TGF α; TGF-alpha; TGFalpha; TGFα; Transforming growth factor; transforming growth factor, alpha
基因别名: TFGA; TGFA
UniProt ID: (Human) P01135
Entrez Gene ID: (Human) 7039