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TGFBR3 Antibody (PA5-17529) in WB
Western blot analysis was performed on whole cell extracts of Hep G2 (Lane 1), undifferentiated C2C12 (Lane 2), differentiated C2C12 (Lane 3), THP-1 (Lane 4), SH-SY5Y (Lane 5), Mouse Adipose (Lane 6) and Mouse Brain (Lane 7). The blot was probed with TGFBR3 Polyclonal Antibody (Product # PA5-17529, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 100kDa band corresponding to TGFBR3 was observed in Hep... View More
产品信息
PA5-17529
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in the extracellular domain of the type III TGF-ß receptor
偶联物
形式
Liquid
浓度
120.8 µg/mL
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11001447
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other family members at physiological conditions.
靶标信息
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Betaglycan; betaglycan proteoglycan; OTTHUMP00000011787; tgf beta receptor 3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3
基因别名: 1110036H20Rik; AU015626; AW215636; betaglycan; BGCAN; TBRIII; TGFBR3
UniProt ID: (Human) Q03167, (Mouse) O88393
Entrez Gene ID: (Human) 7049, (Mouse) 21814
transforming growth factor beta-activated receptor activity
type II transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
protein binding
glycosaminoglycan binding
heparin binding
coreceptor activity
fibroblast growth factor binding
PDZ domain binding
SMAD binding
activin binding
transforming growth factor beta binding
transforming growth factor beta receptor activity, type III
blood vessel development
vasculogenesis
osteoblast differentiation
in utero embryonic development
blastocyst development
epithelial to mesenchymal transition
liver development
blood vessel remodeling
epicardial cell to mesenchymal cell transition
protein complex assembly
protein phosphorylation
immune response
transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor complex assembly
positive regulation of cell proliferation
embryo development
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
cell growth
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
response to follicle-stimulating hormone
response to prostaglandin E
response to luteinizing hormone
intracellular signal transduction
regulation of protein binding
negative regulation of epithelial cell proliferation
regulation of blood vessel size
positive regulation of NF-kappaB transcription factor activity
negative regulation of cellular component movement
ventricular cardiac muscle tissue morphogenesis
palate development
cardiac muscle cell proliferation
definitive hemopoiesis
cardiac epithelial to mesenchymal transition
definitive erythrocyte differentiation
heart trabecula formation
pathway-restricted SMAD protein phosphorylation
coronary vasculature development
coronary vasculature morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
visceral serous pericardium development
negative regulation of apoptotic process involved in morphogenesis
response to hypoxia
heart morphogenesis
cell migration
organ regeneration
