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产品信息
MA5-17187
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1C5H11
抗原
Purified recombinant fragment of human TGFBR3 (amino acids: 147-328 ) expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538658
产品详细信息
MA5-17187 targets TGFBR3 in indirect ELISA, WB applications and shows reactivity with Human and Mouse samples.
The MA5-17187 immunogen is purified recombinant fragment of human TGFBR3 (amino acids: 147-328 ) expressed in E. Coli.
MA5-17187 detects TGFBR3 which has a predicted molecular weight of approximately 93.4kDa.
靶标信息
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Betaglycan; betaglycan proteoglycan; OTTHUMP00000011787; tgf beta receptor 3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3
基因别名: 1110036H20Rik; AU015626; AW215636; betaglycan; BGCAN; TBRIII; TGFBR3
UniProt ID: (Human) Q03167, (Mouse) O88393
Entrez Gene ID: (Human) 7049, (Mouse) 21814
transforming growth factor beta-activated receptor activity
type II transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
protein binding
glycosaminoglycan binding
heparin binding
coreceptor activity
fibroblast growth factor binding
PDZ domain binding
SMAD binding
activin binding
transforming growth factor beta binding
transforming growth factor beta receptor activity, type III
transmembrane signal receptor
response to hypoxia
epithelial to mesenchymal transition
liver development
heart morphogenesis
immune response
transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor complex assembly
cell growth
cell migration
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
organ regeneration
response to follicle-stimulating hormone
response to prostaglandin E
response to luteinizing hormone
intracellular signal transduction
regulation of protein binding
negative regulation of epithelial cell proliferation
negative regulation of cellular component movement
ventricular cardiac muscle tissue morphogenesis
palate development
cardiac muscle cell proliferation
definitive hemopoiesis
cardiac epithelial to mesenchymal transition
definitive erythrocyte differentiation
heart trabecula formation
pathway-restricted SMAD protein phosphorylation
blood vessel development
vasculogenesis
osteoblast differentiation
in utero embryonic development
blastocyst development
blood vessel remodeling
epicardial cell to mesenchymal cell transition
protein complex assembly
protein phosphorylation
positive regulation of cell proliferation
embryo development
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
positive regulation of BMP signaling pathway
regulation of blood vessel size
positive regulation of NF-kappaB transcription factor activity
coronary vasculature development
coronary vasculature morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
visceral serous pericardium development
negative regulation of apoptotic process involved in morphogenesis
