Invitrogen

TGM1 Polyclonal Antibody

TGM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 10

TGM1 Antibody (PA5-59088) in IHC (P)

Immunohistochemical analysis of TGM1 in human skin using TGM1 Polyclonal Antibody (Product # PA5-59088) shows moderate membranous positivity in squamous epithelial cells.

TGM1 Antibody in Immunohistochemistry (IHC)

TGM1 Antibody in Immunocytochemistry (ICC/IF)

Product Image Gallery

TGM1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of TGM1 demonstrates antibody specificity. Immunohistochemical analysis of TGM1 using anti-TGM1 Polyclonal Antibody (Product # PA5-59088), shows significant staining of TGM1 in human esophagus and shows minimal or weak staining in human colon tissues. The relative expression levels of TGM1 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-59088

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:2,500-1:5,000

免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human TGM1. Recombinant protein control fragment (Product #RP-98344).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.20 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2648419

产品详细信息

Immunogen sequence: MMDGPRSDVG RWGGNPLQPP TTPSPEPEPE PDGRSRRGGG RSFWARCCGC CSCRNAADDD WGPEPSDSRG RGSSSGTRRP GSRGSDSRRP VSRGSGVNAA

Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 74%.

靶标信息

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Deep Association between Transglutaminase 1 and Tissue Eosinophil Infiltration Leading to Nasal Polyp Formation and/or Maintenance with Fibrin Polymerization in Chronic Rhinosinusitis with Nasal Polyps.

International journal of molecular sciences

Sonoyama T,Ishino T,Takemoto K,Yamato K,Oda T,Nishida M,Horibe Y,Chikuie N,Kono T,Taruya T,Hamamoto T,Ueda T,Takeno S

PA5-59088 was used in Immunohistochemistry-immunofluorescence to show that TGM 1 influence NP formation and/or maintenance in CRSwNP related to the tissue eosinophil infiltration, which formed fibrin mesh composing NP stroma.

Wed Oct 26 00:00:00 UTC 2022

International journal of molecular sciences

Sonoyama T,Ishino T,Takemoto K,Yamato K,Oda T,Nishida M,Horibe Y,Chikuie N,Kono T,Taruya T,Hamamoto T,Ueda T,Takeno S

Wed Oct 26 00:00:00 UTC 2022

Trichohyalin-like 1 protein plays a crucial role in proliferation and anti-apoptosis of normal human keratinocytes and squamous cell carcinoma cells.

Cell death discovery

Makino T,Mizawa M,Yoshihisa Y,Yamamoto S,Tabuchi Y,Miyai M,Hibino T,Sasahara M,Shimizu T

PA5-59088 was used in Immunohistochemistry to examined the role of Trichohyalin-like 1 in normal human keratinocytes (NHKs) and squamous cell carcinoma (SCC).

Tue Nov 03 00:00:00 UTC 2020

Trichohyalin-like 1 protein plays a crucial role in proliferation and anti-apoptosis of normal human keratinocytes and squamous cell carcinoma cells.

Cell death discovery

Makino T,Mizawa M,Yoshihisa Y,Yamamoto S,Tabuchi Y,Miyai M,Hibino T,Sasahara M,Shimizu T

PA5-59088 was used in Immunohistochemistry to examined the role of Trichohyalin-like 1 in normal human keratinocytes (NHKs) and squamous cell carcinoma (SCC).

Tue Nov 03 00:00:00 UTC 2020

生物信息学

蛋白别名: Epidermal TGase; K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase; Protein-glutamine gamma-glutamyltransferase K; TG(K); TGase K; TGase-1; transglutaminase 1 isoform; Transglutaminase K; transglutaminase, keratinocyte; Transglutaminase-1

查看更多收起

基因别名: ARCI1; ICR2; KTG; LI; LI1; TGASE; TGK; TGM1

查看更多收起

UniProt ID: (Human) P22735

查看更多收起

Entrez Gene ID: (Human) 7051

查看更多收起

功能

protein-glutamine gamma-glutamyltransferase activity protein binding metal ion binding transferase

参与通路

cellular protein modification process positive regulation of keratinocyte proliferation peptide cross-linking keratinocyte differentiation keratinization cell envelope organization positive regulation of cell cycle