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产品信息
PA5-20773
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide near the center of human THEM4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153712
产品详细信息
A suggested positive control is human liver tissue lysate.
PA5-20773 can be used with blocking peptide PEP-0887.
靶标信息
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acyl-CoA thioesterase THEM4; Acyl-coenzyme A thioesterase THEM4; C-terminal modulator protein; Carboxyl-terminal modulator protein; Thioesterase superfamily member 4
基因别名: 2700077M13Rik; 4921507I02Rik; CTMP; RGD1304723; THEM4
UniProt ID: (Human) Q5T1C6, (Rat) Q566R0, (Mouse) Q3UUI3
Entrez Gene ID: (Human) 117145, (Rat) 361992, (Mouse) 75778
