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产品信息
PA5-19240
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (SPEITTEDIKSAFAP) corresponding to the internal amino acids of TIAL1 (aa 105-119).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10983032
产品详细信息
This antibody is predicted to react with bovine, canine and mouse based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
靶标信息
TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Diseases associated with TIAL1 include Salpingitis Isthmica Nodosa and Spinal Muscular Atrophy. Among its related pathways are Signaling by GPCR and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1. The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: aging-associated gene 7 protein; Cytotoxic granule associated RNA binding protein TIA1; MGC33401; Nucleolysin TIA-1 isoform p40; Nucleolysin TIAR; OTTHUMP00000020602; OTTHUMP00000020605; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; T-cluster binding protein; TIA-1; TIA-1-related nucleolysin; TIA-1-related protein
基因别名: TCBP; TIA-1; TIA1; TIAL1; TIAR; WDM
UniProt ID: (Human) P31483, (Human) Q01085
Entrez Gene ID: (Human) 7072, (Human) 7073
apoptotic process
fibroblast growth factor receptor signaling pathway
negative regulation of translation
negative regulation of cytokine biosynthetic process
regulation of mRNA splicing, via spliceosome
protein localization to cytoplasmic stress granule
positive regulation of epithelial cell apoptotic process
regulation of transcription from RNA polymerase II promoter
defense response
germ cell development
positive regulation of cell proliferation
stem cell division
