Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
TLR8 Antibody (MA5-16194) in Flow
Flow cytometry of TLR8 in Ramos cells. Samples were incubated in TLR8 monoclonal antibody (Product # MA5-16194) using a dilution of 2 µg. Shaded histogram represents Ramos cells without antibody; green represents isotype control; red represents anti-TLR8 antibody.
产品信息
MA5-16194
产品规格
种属反应
Human,
Mouse,
Rabbit
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
44C143
抗原
A KLH-conjugated synthetic peptide of human TLR8, within amino acids 750-850.
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
0.70 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2537713
靶标信息
The TLR8 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
生物信息学
蛋白别名: CD antigen 288; CD288; Toll-like receptor 8
基因别名: CD288; TLR8; UNQ249/PRO286
UniProt ID: (Human) Q9NR97, (Mouse) P58682
Entrez Gene ID: (Human) 51311, (Mouse) 170744
microglial cell activation
regulation of protein phosphorylation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
response to virus
toll-like receptor 8 signaling pathway
positive regulation of interferon-gamma biosynthetic process
innate immune response
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
defense response to virus
immunoglobulin mediated immune response
toll-like receptor 9 signaling pathway
cellular response to mechanical stimulus
