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产品信息
PA5-34555
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid peptide near the amino terminus of human TLX3
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551907
产品详细信息
A suggested positive control is human spleen tissue lysate.
PA5-34555 can be used with blocking peptide PEP-1598.
靶标信息
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: homeo box 11-like 2; homeobox 11-like 2; Homeobox protein Hox-11L2; Homeobox TLX-3; Respiratory neuron homeobox protein; T-cell leukemia homeobox protein 3; T-cell leukemia, homeobox 3
基因别名: HOX11L2; RGD1564190; RNX; Tlx1l2; TLX3
UniProt ID: (Human) O43711, (Mouse) O55144
Entrez Gene ID: (Human) 30012, (Mouse) 27140, (Rat) 497881
cell fate specification
neuron migration
regulation of respiratory gaseous exchange by neurological system process
regulation of transcription, DNA-templated
multicellular organism development
central nervous system development
respiratory gaseous exchange
neuron differentiation
negative regulation of neuron differentiation
neuron fate specification
