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TLX3 Antibody (PA5-85574) in IHC (P)
TLX3 Polyclonal Antibody detects TLX3 protein at nucleus on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. TLX3 Polyclonal Antibody (Product # PA5-85574) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-85574
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TLX3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792714
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Xenopus laevis (100%), Chicken (100%), Bovine (100%).
Positive Control: SK-N-SH, IMR32, SK-N-AS.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box 11-like 2; homeobox 11-like 2; Homeobox protein Hox-11L2; Homeobox TLX-3; Respiratory neuron homeobox protein; T-cell leukemia homeobox protein 3; T-cell leukemia, homeobox 3
基因别名: HOX11L2; RNX; Tlx1l2; TLX3
UniProt ID: (Human) O43711, (Mouse) O55144
Entrez Gene ID: (Human) 30012, (Mouse) 27140
cell fate specification
neuron migration
regulation of respiratory gaseous exchange by neurological system process
regulation of transcription, DNA-templated
multicellular organism development
central nervous system development
respiratory gaseous exchange
neuron differentiation
negative regulation of neuron differentiation
neuron fate specification
