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TMC1 (extracellular) Antibody (ATC-010-200UL) in WB
Western blot analysis ofhuman THP-1monocyticleukemia cell line lysate (lanes 1 and4),human HL-60promyelocyticleukemia cell line lysate (lanes 2 and5)andhuman 132N1 astrocytoma cell line lysate (lanes 3 and 6): - 1-3. Anti-TMC1 (extracellular) Antibody (#ATC-010), (1:200).4-6. Anti-TMC1 (extracellular) Antibody ,preincubated with TMC1 (extracellular)Blocking Peptide (BLP-TC010).
产品信息
ATC-010-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EHDFPSWMAKILR, corresponding to amino acid residues 679-691 of mouse TMC1, Extracellular, 3rd loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beethoven protein; Deafness protein; transmembrane channel-like 1; Transmembrane channel-like protein 1; Transmembrane cochlear-expressed protein 1; transmembrane, cochlear expressed 1; transmembrane, cochlear expressed, 1
基因别名: 4933416G09Rik; Beethoven; Bth; CWEA1; DFNA36; DFNB11; DFNB7; dn; TMC1
UniProt ID: (Human) Q8TDI8, (Mouse) Q8R4P5
Entrez Gene ID: (Human) 117531, (Mouse) 13409, (Rat) 361739
