Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-20858
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide from near the carboxy terminus of human TMEM38A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152506
产品详细信息
A suggested positive control is rat skeletal muscle tissue lysate.
PA5-20858 can be used with blocking peptide PEP-0972.
靶标信息
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 27 kDa sarcoplasmic reticulum protein; Mitsugumin-33A; Mitsugumin33A; sarcoplasmic reticulum protein 27; SPR-27; tmem38a {ECO:0000250|UniProtKB:Q3TMP8}; Transmembrane protein 38A; TRIC-A; TRICA; Trimeric intracellular cation channel type A
基因别名: 1110001E17Rik; AI413399; mg33a; RGD1307901; Srp-27; TMEM38A; TRIC-A; TRICA
UniProt ID: (Human) Q9H6F2, (Mouse) Q3TMP8, (Rat) A6ZIQ8
Entrez Gene ID: (Human) 79041, (Mouse) 74166, (Rat) 306327
