Invitrogen

TMEM38B Polyclonal Antibody

TMEM38B Antibody in Immunohistochemistry (IHC)

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TMEM38B Antibody (PA5-20859) in IHC

Immunohistochemistry of TMEM38B in mouse thymus tissue with TMEM38B Polyclonal Antibody (Product # PA5-20859) at 5 µg/mL.

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产品信息

PA5-20859

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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免疫组化 (IHC)

5 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A 17 amino acid peptide from near the carboxy terminus of human TMEM38B.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11152440

产品详细信息

A suggested positive control is rat thymus tissue lysate.

PA5-20859 can be used with blocking peptide PEP-0973.

靶标信息

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes.

PLoS biology

Shrestha N,Bacsa B,Ong HL,Scheruebel S,Bischof H,Malli R,Ambudkar IS,Groschner K

PA5-20859 was used in Western Blotting to demonstrate that TRIC-A is a negative regulator of STIM1/Orai1 function. Thus, aberrant SOCE could contribute to muscle disorders associated with loss of TRIC-A.

Wed Apr 01 00:00:00 UTC 2020

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response.

Cell reports

Fink EE,Moparthy S,Bagati A,Bianchi-Smiraglia A,Lipchick BC,Wolff DW,Roll MV,Wang J,Liu S,Bakin AV,Kandel ES,Lee AH,Nikiforov MA

PA5-20859 was used in Western Blot to identify a role for XBP1s in cytotoxic unfolded protein response and provide insights into mechanisms of life-or-death decisions in cells under endoplasmic reticulum stress.

Tue Oct 02 00:00:00 UTC 2018

Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta.

PLoS genetics

Cabral WA,Ishikawa M,Garten M,Makareeva EN,Sargent BM,Weis M,Barnes AM,Webb EA,Shaw NJ,Ala-Kokko L,Lacbawan FL,Högler W,Leikin S,Blank PS,Zimmerberg J,Eyre DR,Yamada Y,Marini JC