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TMEM59 Antibody (PA5-21575) in IHC (P)
TMEM59 Polyclonal Antibody detects TMEM59 protein at cytosol on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human ovarian carcinoma. TMEM59 Polyclonal Antibody (Product # PA5-21575) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-21575
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 16 and 311 of TMEM59 (Uniprot ID#Q9BXS4)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11154807
产品详细信息
Recommended positive controls: A431, mouse liver, rat kidney.
Predicted reactivity: Mouse (95%), Rat (94%), Pig (96%), Chicken (83%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: dendritic cell factor 1; Liver membrane-bound protein; RP4-758J24.2; Thymic dendritic cell-derived factor 1; Transmembrane protein 59
基因别名: 1110001M20Rik; 3110046P06Rik; AI256529; C1orf8; D4Ertd20e; DCF1; HSPC001; MTDCF1; ORF18; PRO195; RGD1310313; Tdcf1; TMEM59; UNQ169; UNQ169/PRO195
UniProt ID: (Human) Q9BXS4, (Mouse) Q9QY73
Entrez Gene ID: (Human) 9528, (Mouse) 56374, (Rat) 100196907
