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产品信息
OST00230G-500UG
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the c-terminal of TMP21 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in many species including rat and mouse.
Specificity of this antibody: TMP21.
靶标信息
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); p23; p24 family protein delta-1; p24delta; p24delta1; Protein TMED10; S31I125; S31III125; testicular tissue protein Li 206; Tmp-21-I; Transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; Transmembrane protein Tmp21; transmembrane trafficking protein; transmembrane trafficking protein 21
基因别名: 1110014C03Rik; p23; P24(DELTA); p24d1; p24delta1; S31I125; S31III125; TMED10; Tmp-21-I; TMP21
UniProt ID: (Human) P49755, (Rat) Q63584, (Mouse) Q9D1D4
Entrez Gene ID: (Human) 10972, (Rat) 84599, (Mouse) 68581
kidney development
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
Golgi organization
cargo loading into vesicle
COPI-coated vesicle budding
response to alkaloid
regulated exocytosis
vesicle targeting, to, from or within Golgi
COPI coating of Golgi vesicle
COPII vesicle coating
protein oligomerization
regulation of beta-amyloid formation
vesicle targeting
transport
protein transport
vesicle-mediated transport
