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TMSB4X Antibody (PA5-100118) in ICC/IF
Immunofluorescent analysis of TMSB4X in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and TMSB4X polyclonal antibody (Product # PA5-100118) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-100118
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TMSB4X(Accession P62328), corresponding to amino acid residues M1-K32.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815648
产品详细信息
Antibody detects endogenous levels of total TMSB4X.
靶标信息
Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family that is found at high concentrations within the spleen, thymus, and peritoneal macrophages, where it is most notably responsible for the organization of cytoskeletal structure. In mammalian tissues, this protein acts as a modulator for the polymerization/depolymerization of actin through the formation of a 1:1 complex with the monomer G (globular)-actin, and inhibits actin's polymerization to form F (filamentous) actin, which together with other proteins binds microfilaments to construct the cytoskeleton. Commonly found at significant quantities within the brain, lungs, liver, kidneys, testes, and heart, thymosin-beta4 has also been shown to be synthesized by cells unrelated to the reticuloendothelial system, such as myoblasts and fibroblasts, and expressed at irregular levels by several hemopoietic cell lines, malignant lymphoid cells and myeloma cells. In addition to regulating actin polymerization, research has also found thymosin-beta4 to stimulate the secretion of hypothalamic luteinizing hormone-releasing hormone and luteinizing hormone, inhibit the migration of peritoneal macrophages, induce phenotypic changes in T cell lines during early host defense mechanisms, and inhibit the progression of hematopoietic pluripotent stem cells into the S-phase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fx; prothymosin beta 4; prothymosin beta-4; T beta 4; T beta-4; TB4Xbeta 4; thymosin; thymosin beta 4; Thymosin beta-4; thymosin, beta 4, X chromosome
基因别名: FX; PTMB4; Tb4; TB4X; THYB4; TMSB4; TMSB4X
UniProt ID: (Human) P62328, (Rat) P62329, (Mouse) P20065
Entrez Gene ID: (Human) 7114, (Rat) 81814, (Mouse) 19241
osteoblast differentiation
actin filament organization
regulation of cell migration
sequestering of actin monomers
positive regulation of smooth muscle cell migration
actin cytoskeleton organization
positive regulation of transcription, DNA-templated
positive regulation of smooth muscle cell differentiation
platelet degranulation
