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TNNI1 Antibody (PA5-145255) in WB
Western blot analysis of TNNI1 in various lysates. Samples were incubated with TNNI1 polyclonal antibody (Product # PA5-145255) using a dilution of 0.2 µg/mL followed by HRP-Linked Caprine Anti-Rabbit IgG secondary antibody at a dilution of 0.2 µg/mL. Lane 1: Rat Heart lysate; Lane 2: Rat Skeletal muscle lysate; Lane 3: Mouse Heart lysate; Lane 4: Mouse Skeletal muscle lysate.
产品信息
PA5-145255
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Rat TNNI1 protein, Met1-Gln187 (Accession #P13413)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% Proclin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3094064
靶标信息
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: slow-twitch skeletal isoform; SSTNI; TNN1; troponin I skeletal slow-twitch protein; troponin I type 1 (skeletal, slow); troponin I, skeletal, slow 1; Troponin I, slow isoform; Troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform
基因别名: 2700018B22Rik; AI747285; SSTNI; TnI-S4; TNN1; TNNI1
UniProt ID: (Human) P19237, (Mouse) Q9WUZ5, (Rat) P13413
Entrez Gene ID: (Human) 7135, (Pig) 396947, (Mouse) 21952, (Rat) 29388
