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产品信息
MA5-15913
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2F12A8
抗原
Purified recombinant fragment of human TNNI2 expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11156210
产品详细信息
MA5-15913 targets TNNI2 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15913 immunogen is purified recombinant fragment of human TNNI2 expressed in E. Coli. .
MA5-15913 detects TNNI2 which has a predicted molecular weight of approximately 21kDa.
靶标信息
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: troponin I fast twitch 2; troponin I type 2 (skeletal, fast); Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast
基因别名: AMCD2B; DA2B; FSSV; fsTnI; TNNI2
UniProt ID: (Human) P48788, (Mouse) P13412
Entrez Gene ID: (Human) 7136, (Mouse) 21953
