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产品信息
PA5-84381
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.07 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2791533
产品详细信息
Immunogen sequence: EEEEAPEEPE PVAEPEEERP KPSRPVVPPL IPPKIPEGE
靶标信息
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
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生物信息学
蛋白别名: MGC104241; Slow skeletal muscle troponin T; sTnT; TnTs; troponin T type 1 (skeletal, slow); Troponin T, slow skeletal muscle; troponin-T1, skeletal, slow
基因别名: ANM; NEM5; STNT; TNNT1; TNT; TNTS
UniProt ID: (Human) P13805
Entrez Gene ID: (Human) 7138
