Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-55498
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human TPCN2. Recombinant protein control fragment (Product #RP-91224).
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2648839
产品详细信息
Immunogen sequence: QFRGYLMKSL QTSLFRRRLG TRAAFEVLSS MVGEGGAFPQ AVGVKPQNLL QVLQKVQLDS SHRQAMMEKV RSYGSVLLSA EEFQKLFNEL DRSVVKEHPP RPEYQSPFLQ SAQFLFGHYY F
Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 63%.
靶标信息
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Two pore calcium channel protein 2; Two pore channel protein 2; two-pore calcium channel protein 2; voltage-dependent calcium channel protein TPC2
基因别名: SHEP10; TPC2; TPCN2
UniProt ID: (Human) Q8NHX9
Entrez Gene ID: (Human) 219931
cellular calcium ion homeostasis
smooth muscle contraction
lysosome organization
regulation of autophagy
calcium-mediated signaling
response to vitamin D
ion transmembrane transport
regulation of ion transmembrane transport
release of sequestered calcium ion into cytosol
membrane depolarization during action potential
