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产品信息
PA5-88151
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human Tropomyosin 1 (NP_0010180081)
偶联物
形式
Liquid
浓度
0.51 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804693
产品详细信息
Immunogen sequence: MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNELKL ALNED; Positive Samples: A-549, BT-474, THP-1, DU145, SW480, MCF7, Mouse heart, Mouse skeletal muscle, Mouse brain; Cellular Location: Cytoplasm, cytoskeleton
靶标信息
Tropomyosin is a dimeric coiled-coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F-actin filaments, and the lack of proline and tryptophan.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha tropomyosin; Alpha-tropomyosin; cardiomyopathy, hypertrophic 3; epididymis secretory protein Li 265; sarcomeric tropomyosin kappa; TPM1-alpha; tropomyosin; Tropomyosin alpha-1 chain; Tropomyosin-1
基因别名: AA986836; AI854628; alpha-TM; C15orf13; CMD1Y; CMH3; HEL-S-265; HTM-alpha; LVNC9; TM2; Tm3; Tmpa; TMSA; Tpm-1; TPM1; Tpma
UniProt ID: (Human) P09493, (Mouse) P46902
Entrez Gene ID: (Human) 7168, (Mouse) 22003
in utero embryonic development
positive regulation of heart rate by epinephrine
movement of cell or subcellular component
muscle contraction
regulation of muscle contraction
cytoskeleton organization
regulation of heart contraction
regulation of cell shape
muscle filament sliding
negative regulation of cell migration
ruffle organization
positive regulation of ATPase activity
cellular response to reactive oxygen species
wound healing
sarcomere organization
positive regulation of cell adhesion
positive regulation of stress fiber assembly
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
embryo development
regulation of ATPase activity
actin filament capping
