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TPMT Antibody (MA5-44759) in IHC (P)
Immunohistochemistry analysis of TPMT in paraffin-embedded mouse hippocampus tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with TPMT Monoclonal antibody (Product # MA5-44759) using a dilution of 1:400 for 1 hour at room t... View More
产品信息
MA5-44759
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE64-09
抗原
Synthetic peptide within human TPMT aa 101-150/245.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2931217
靶标信息
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGNC:12014; S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase; Thiopurine S-methyltransferase
基因别名: AW106912; TPMT; TPMTD
UniProt ID: (Human) O15424, (Mouse) O55060
Entrez Gene ID: (Human) 7172, (Rat) 690050, (Mouse) 22017
