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产品信息
PA5-89193
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human TCTP/TCTP/TPT1 (NP_0032861)
偶联物
形式
Liquid
浓度
0.65 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805408
产品详细信息
Immunogen sequence: MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KC; Positive Samples: K-562, THP-1, Mouse kidney; Cellular Location: Cytoplasm
靶标信息
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
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生物信息学
蛋白别名: 21 kDa polypeptide; 21 kDa polypeptide under translational control; Fortilin; Histamine-releasing factor; HRF; p21; p23; TCTP; translationally regulated transcript (21 kDa); Translationally-controlled tumor protein
基因别名: HRF; p02; p21; p23; TCTP; TPT1; Trt
UniProt ID: (Human) P13693, (Mouse) P63028
Entrez Gene ID: (Human) 7178, (Mouse) 22070
calcium ion transport
cellular calcium ion homeostasis
response to virus
cell differentiation
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
stem cell population maintenance
negative regulation of ectoderm development
